Competition between Phytophthora infestans effectors leads to increased aggressiveness on plants containing broad-spectrum late blight resistance.
Identifieur interne : 001958 ( Main/Exploration ); précédent : 001957; suivant : 001959Competition between Phytophthora infestans effectors leads to increased aggressiveness on plants containing broad-spectrum late blight resistance.
Auteurs : Dennis A. Halterman [États-Unis] ; Yu Chen ; Jiraphan Sopee ; Julio Berduo-Sandoval ; Amilcar Sánchez-PérezSource :
- PloS one [ 1932-6203 ] ; 2010.
Descripteurs français
- KwdFr :
- Analyse de regroupements (MeSH), Analyse de séquence d'ADN (MeSH), Feuilles de plante (microbiologie), Gènes de plante (génétique), Immunité innée (immunologie), Interactions hôte-pathogène (MeSH), Maladies des plantes (immunologie), Maladies des plantes (microbiologie), Peptides (classification), Phytophthora infestans (métabolisme), Protéines d'algue (métabolisme), Solanum tuberosum (génétique), Solanum tuberosum (immunologie), Solanum tuberosum (microbiologie), Séquence d'acides aminés (MeSH).
- MESH :
- classification : Peptides.
- génétique : Gènes de plante, Solanum tuberosum.
- immunologie : Immunité innée, Maladies des plantes, Solanum tuberosum.
- microbiologie : Feuilles de plante, Maladies des plantes, Solanum tuberosum.
- métabolisme : Phytophthora infestans, Protéines d'algue.
- Analyse de regroupements, Analyse de séquence d'ADN, Interactions hôte-pathogène, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Algal Proteins (metabolism), Amino Acid Sequence (MeSH), Cluster Analysis (MeSH), Genes, Plant (genetics), Host-Pathogen Interactions (MeSH), Immunity, Innate (immunology), Peptides (classification), Phytophthora infestans (metabolism), Plant Diseases (immunology), Plant Diseases (microbiology), Plant Leaves (microbiology), Sequence Analysis, DNA (MeSH), Solanum tuberosum (genetics), Solanum tuberosum (immunology), Solanum tuberosum (microbiology).
- MESH :
- chemical , classification : Peptides.
- chemical , metabolism : Algal Proteins.
- genetics : Genes, Plant, Solanum tuberosum.
- immunology : Immunity, Innate, Plant Diseases, Solanum tuberosum.
- metabolism : Phytophthora infestans.
- microbiology : Plant Diseases, Plant Leaves, Solanum tuberosum.
- Amino Acid Sequence, Cluster Analysis, Host-Pathogen Interactions, Sequence Analysis, DNA.
Abstract
BACKGROUND
The destructive plant disease potato late blight is caused by the oomycete pathogen Phytophthora infestans (Mont.) de Bary. This disease has remained particularly problematic despite intensive breeding efforts to integrate resistance into cultivated potato, largely because of the pathogen's ability to quickly evolve to overcome major resistance genes. The RB gene, identified in the wild potato species S. bulbocastanum, encodes a protein that confers broad-spectrum resistance to most P. infestans isolates through its recognition of highly conserved members of the corresponding pathogen effector family IPI-O. IpiO is a multigene family of effectors and while the majority of IPI-O proteins are recognized by RB to elicit host resistance, some variants exist that are able to elude detection (e.g. IPI-O4).
METHODS AND FINDINGS
In the present study, analysis of ipiO variants among 40 different P. infestans isolates collected from Guatemala, Thailand, and the United States revealed a high degree of complexity within this gene family. Isolate aggressiveness was correlated with increased ipiO diversity and especially the presence of the ipiO4 variant. Furthermore, isolates expressing IPI-O4 overcame RB-mediated resistance in transgenic potato plants even when the resistance-eliciting IPI-O1 variant was present. In support of this finding, we observed that expression of IPI-O4 via Agrobacterium blocked recognition of IPI-O1, leading to inactivation of RB-mediated programmed cell death in Nicotiana benthamiana.
CONCLUSIONS
In this study we definitively demonstrate and provide the first evidence that P. infestans can defeat an R protein through inhibition of recognition of the corresponding effector protein.
DOI: 10.1371/journal.pone.0010536
PubMed: 20479869
PubMed Central: PMC2866322
Affiliations:
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Halterman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America. dennis.halterman@ars.usda.gov</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name></author><author><name sortKey="Sopee, Jiraphan" sort="Sopee, Jiraphan" uniqKey="Sopee J" first="Jiraphan" last="Sopee">Jiraphan Sopee</name></author><author><name sortKey="Berduo Sandoval, Julio" sort="Berduo Sandoval, Julio" uniqKey="Berduo Sandoval J" first="Julio" last="Berduo-Sandoval">Julio Berduo-Sandoval</name></author><author><name sortKey="Sanchez Perez, Amilcar" sort="Sanchez Perez, Amilcar" uniqKey="Sanchez Perez A" first="Amilcar" last="Sánchez-Pérez">Amilcar Sánchez-Pérez</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20479869</idno><idno type="pmid">20479869</idno><idno type="doi">10.1371/journal.pone.0010536</idno><idno type="pmc">PMC2866322</idno><idno type="wicri:Area/Main/Corpus">001904</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001904</idno><idno type="wicri:Area/Main/Curation">001904</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001904</idno><idno type="wicri:Area/Main/Exploration">001904</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Competition between Phytophthora infestans effectors leads to increased aggressiveness on plants containing broad-spectrum late blight resistance.</title><author><name sortKey="Halterman, Dennis A" sort="Halterman, Dennis A" uniqKey="Halterman D" first="Dennis A" last="Halterman">Dennis A. 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This disease has remained particularly problematic despite intensive breeding efforts to integrate resistance into cultivated potato, largely because of the pathogen's ability to quickly evolve to overcome major resistance genes. The RB gene, identified in the wild potato species S. bulbocastanum, encodes a protein that confers broad-spectrum resistance to most P. infestans isolates through its recognition of highly conserved members of the corresponding pathogen effector family IPI-O. IpiO is a multigene family of effectors and while the majority of IPI-O proteins are recognized by RB to elicit host resistance, some variants exist that are able to elude detection (e.g. IPI-O4).</p></div><div type="abstract" xml:lang="en"><p><b>METHODS AND FINDINGS</b></p><p>In the present study, analysis of ipiO variants among 40 different P. infestans isolates collected from Guatemala, Thailand, and the United States revealed a high degree of complexity within this gene family. Isolate aggressiveness was correlated with increased ipiO diversity and especially the presence of the ipiO4 variant. Furthermore, isolates expressing IPI-O4 overcame RB-mediated resistance in transgenic potato plants even when the resistance-eliciting IPI-O1 variant was present. In support of this finding, we observed that expression of IPI-O4 via Agrobacterium blocked recognition of IPI-O1, leading to inactivation of RB-mediated programmed cell death in Nicotiana benthamiana.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>In this study we definitively demonstrate and provide the first evidence that P. infestans can defeat an R protein through inhibition of recognition of the corresponding effector protein.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20479869</PMID><DateCompleted><Year>2010</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>5</Issue><PubDate><Year>2010</Year><Month>May</Month><Day>07</Day></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS One</ISOAbbreviation></Journal><ArticleTitle>Competition between Phytophthora infestans effectors leads to increased aggressiveness on plants containing broad-spectrum late blight resistance.</ArticleTitle><Pagination><MedlinePgn>e10536</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0010536</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The destructive plant disease potato late blight is caused by the oomycete pathogen Phytophthora infestans (Mont.) de Bary. This disease has remained particularly problematic despite intensive breeding efforts to integrate resistance into cultivated potato, largely because of the pathogen's ability to quickly evolve to overcome major resistance genes. The RB gene, identified in the wild potato species S. bulbocastanum, encodes a protein that confers broad-spectrum resistance to most P. infestans isolates through its recognition of highly conserved members of the corresponding pathogen effector family IPI-O. IpiO is a multigene family of effectors and while the majority of IPI-O proteins are recognized by RB to elicit host resistance, some variants exist that are able to elude detection (e.g. IPI-O4).</AbstractText><AbstractText Label="METHODS AND FINDINGS" NlmCategory="RESULTS">In the present study, analysis of ipiO variants among 40 different P. infestans isolates collected from Guatemala, Thailand, and the United States revealed a high degree of complexity within this gene family. Isolate aggressiveness was correlated with increased ipiO diversity and especially the presence of the ipiO4 variant. Furthermore, isolates expressing IPI-O4 overcame RB-mediated resistance in transgenic potato plants even when the resistance-eliciting IPI-O1 variant was present. In support of this finding, we observed that expression of IPI-O4 via Agrobacterium blocked recognition of IPI-O1, leading to inactivation of RB-mediated programmed cell death in Nicotiana benthamiana.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In this study we definitively demonstrate and provide the first evidence that P. infestans can defeat an R protein through inhibition of recognition of the corresponding effector protein.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Halterman</LastName><ForeName>Dennis A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America. dennis.halterman@ars.usda.gov</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yu</ForeName><Initials>Y</Initials></Author><Author 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last="Berduo-Sandoval">Julio Berduo-Sandoval</name><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name><name sortKey="Sanchez Perez, Amilcar" sort="Sanchez Perez, Amilcar" uniqKey="Sanchez Perez A" first="Amilcar" last="Sánchez-Pérez">Amilcar Sánchez-Pérez</name><name sortKey="Sopee, Jiraphan" sort="Sopee, Jiraphan" uniqKey="Sopee J" first="Jiraphan" last="Sopee">Jiraphan Sopee</name></noCountry><country name="États-Unis"><region name="Wisconsin"><name sortKey="Halterman, Dennis A" sort="Halterman, Dennis A" uniqKey="Halterman D" first="Dennis A" last="Halterman">Dennis A. 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